Email:
info@beikebiotech.com
Information on Treatment with Shenzhen Beike Biotech Co, Ltd - Shenzhen, P.R.C
I N F O R M A T I O N O N T R E A T M E N T
I N T R O D U C T I O N –
T R E A T M
· 4 stem cell injections (with a minimum of 10,000,000 cells each) ( 5-7 days between each injection)
· 1 month stay in hospital with one caregiver
· Daily rehabilitation program twice per day (six days a week)
· Transportation from and to the airport
1. G E T T I N G T H E R E A N D A C C O M M O D A T I O N
Flights
The best way to get to Nan Shan Hospital is to fly into Shenzhen Airport where you will be picked up by Beike at the airport and driven to the hospital by van which will take about 20 minutes. If you need special accommodations in the van, it is important to let us know. The second best way to get to Nan Shan hospital is to fly to Hong Kong and as soon as you get off the plane, go to the Shekou Ferry terminal. The ferry staff will go and get your bags and put them straight onto the ferry and you will only go through customs in China. The ferry takes about 30 minutes and once you arrive in Shekou, Shenzhen, the Beike staff will be there to pick you up and it is about a 15 minute ride to Nan Shan hospital. The last way to get to Nan Shan hospital is to take a flight into Hong Kong and get picked up at the airport by the Beike staff. In this way, you will have to go through customs twice, first at the Hong Kong airport and then in the van at the Hong Kong / Shenzhen border. The ride from Hong Kong airport to Nan Shan hospital will take about 2 ˝ hours. This is a good option if your airplane arrives before 6:00 a.m. or after 10:00 p.m. To get into Hong Kong, citizens of most countries will not need a visa but to enter China, everyone will.
Visas
We believe that a good way to get a visa for China in places like the United States is to go to Triple A but if your local travel agent can process the visa in a timely manner then please use them. For example, in America, there is a Chinese Embassy in the Washington D.C. and consulates in New York, Chicago, San Francisco, Los Angeles and Houston. Please see http://www.china-embassy.org/eng/hzqz/t84229.htm for details. If you live in one of those cities, then it may convenient to get your visa directly from the consulate though it is usually easier to deal with Triple A. You should allow for a 7-10 days for the visa process.
There is also a service which some patients have said is excellent. Their web site can be found at http://www.visa4you.com. Their phone number is 800-884-7579. If you are American and need to rush your passport, you can go to http://www.itseasypassports.com or call 2122868500.
UK Residents can go to one of your local Chinese consulates to pick up your visa. It is quite straight forward for UK citizens to get a visa for China.
Some countries in Eastern Europe require an invitation letter. If that is the case, let us know and we will write one up for you and get it to you as soon as we can.
Vaccinations
While no vaccinations are required by the Chinese government for entry into China, it is recommended by many travel organizations that visitors get the standard inoculations for polio, diphtheria, and tetanus, while additional inoculations may be against meningococcal meningitis, cholera, typhoid fever, hepatitis A and B, and Japanese B encephalitis before coming.
Weather
The weather in Shenzhen is relatively warm throughout the year. It is very hot in the summer and not too cold in the winter. During the months of January, February and March, you should bring long sleeve shirts, sweaters and coats. For a current weather forecast, go to http://asia.weather.yahoo.com/CHXX/CHXX0120/index_c.html if your are European and go to http://www.wunderground.com/global/stations/59493.html if you are American.
Arrival
You
will be picked up at the airport or ferry station immediately and there will be
someone waiting right outside of the gate with signs with the names of both you
and the person who accompanies you on them. Many patients will be escorted in
wheelchairs by the airport staff. Sometimes they will escort you out a special
gate but they will always bring you back to the exit where you were supposed to
come out of. In the Hong Kong airport there are two gates – A and B. In
Guangzhou and Shenzhen there is just one gate.
Accommodation
You will be staying on the 19th floor of Nan Shan Hospital. Nan Shan is the biggest hospital in the Western part of Shenzhen with over 1,000 beds and over 1,000 employees. The neurosurgery department has eleven doctors and the most modern medical facilities and equipment. The hospital room in China is as comfortable as most standard hospital rooms in the United States. Each room has internet access if you decide to bring your laptop, a television and a DVD player. DVDs cost less than US $1 in China and they have most of the latest movies. There is also a common room with a collection of books, DVDs and magazines. Please bring any magazines you have laying around for others to enjoy.
Hospital Address:
Attn: Amy Pan
Nanshan Hospital (Rm. 1925)
#1 Tao Yuan Road
Shenzhen, 518052
People’s Republic of China
Money
You should transfer the fee for your treatment and stay in the hospital before arriving. This will cover all your stay in the hospital, the stem cell injections, nerve growth factor injections, and rehabilitation. You should bring at least an extra US $1,000 for meals, drinks, snacks, eating out and sightseeing. Travellers Checks are difficult to use in China and no foreign currency is accepted directly. It is best to bring cash and exchange the money when you get to Shenzhen. The day after you arrive, we will take you to the bank and give you a tour of the various stores and restaurants around the area. You most likely will also be able to withdraw RMB (Chinese money) using your bank card as there are many banks that take international bank cards and debit cards like Visa and Mastercard. International credit cards in China are only taken at the nicest restaurants and shopping centers. It is best not to rely on your credit card while here.
The exchange rate is about US $1 to 8 RMB (Chinese Currency). You can wait until you get to China to change money. You will not need to spend any money the first day when you arrive and you will be brought to the bank the next day to change money after you have settled in.
The payment should be a transfer at least one week before arrival to guarantee deposit before arrival.
Please send a copy of the transfer information by email or fax to +86 755 26476005. You must at least send a transfer reference number after making the transfer
Transfer the USD funds (by T/T via CHIPS) as follows:
Within China:
(1) Beneficiary
Bank Name: China Merchants Bank, H.O. Shenzhen: Swift code: CMBCCNBS
(2) Beneficiary Account Number: 1981392910001
(3) Beneficiary Account Name: Shenzhen Beike
Biotechnology Co., Ltd
(4) Remarks: /TELE/pay through CMB Shenzhen (city) Branch
From Overseas:
Beneficiary Bank Name: HSBC Hong Kong : Swift Code: HSBCHKHHHKH
Beneficiary Bank Address: 1 Queen’s Road, Hong Kong
Beneficiary Account Name: Orient Joy Group Limited
Beneficiary Account Number: 808-060933-838
Hotels
If you have more than one caretaker / friend coming then there is an assortment of hotels at a range of prices from US $20 per night to US $80 per night nearby the hospital. Please let us know what your budget is and how many rooms you need at least a week before your trip.
Leaving the Hospital, Food and Amenities
Depending on your condition, you will be allowed to
leave the hospital if you are feeling up to it. Most of your travel will be
done by taxis though we may have a car and driver available for you for
specific circumstances. Taxis will cost you anywhere between US $1 to $10
dollars. There is a restaurant at the hospital has western and Chinese food.
You can either go down to the restaurant or have them send food up to your
room. Please let us know one week in advance if you have any allergies to
certain types of food or anything you like or do not like. You can also go out
to nearby restaurants to try the local cuisine. Japanese, Korean, and all kinds
of Chinese restaurants are plentiful in the area. There are two small convenience stores that
have all types of drinks, snacks, fruit and toiletries and are open twenty-hour
hours a day on the first floor of the hospital. Patients should bring at least
US $1,000 for meals, gifts, travel for one patient and
one caregiver.
2. T R E A T M E N T
Stem Cell Preparation
For
most treatments, stem cells from umbilical cord blood (UCB) are used. Following
the birth of a baby, the umbilical cord usually is discarded along with the
placenta. However, it is now known that blood retrieved from the umbilical cord
is a rich source of stem cells. Stem cells are unspecialized cells that can
develop into specialized cells such as a muscle cell, a red blood cell, or a
brain cell.
After a woman consents to donate her umbilical cord blood, her medical history is examined to ensure there is no potential that she has any hereditary or genetic diseases. Once this is confirmed and immediately after the baby is born and the umbilical cord is detached, a needle is inserted into the cord’s vein and the placenta blood is drawn. Between 80 to 140 ml of umbilical cord blood is collected in a small, sterile pouch that contains an anticoagulant to prevent clotting by authorized hospital staff.
The umbilical cord blood is sent immediately to the city government blood bank for testing for infectious diseases including: syphilis, hepatitis, HTLV, HIV and CMV. It is also tested to confirm the absence of microbiological contamination.
If the blood pasts all tests, it is delivered along with a certification of purity from the blood bank to the Beike laboratory.
The cells are then tested one more time by the Beike laboratory staff to qualify the blood banks results. This is a double check to ensure safety to the patients. At the laboratory, cells are isolated through a combination of enrichment using magnetic beads coated with antibodies to stem cell antigens and multiparameter flow cytometry to produce highly purified live stem cell populations.
Then the cells are placed a proprietary medium which contains no animal products or byproducts and will grow for 7 to 10 days. During that time some of the unnecessary cells die off and leaving only the stem cells. The medium is changed every 1 to 2 days and the cells are tested for activity and content. If there is any sign of unwanted behavior or contamination, the batch of stem cells is thrown out and not used.
After 7 to 10 days, the cells are isolated and purified again. The number of cells are counted with the final product having at least 10,000,000 stem cells including CD+34 and CD+133 cells. A certification with numbers of stem cells is given by the lab and the stem cells are delivered to Nan Shan hospital which is a ten minute drive from Beike’s laboratory in Shenzhen.
A potentially fatal complication called graft versus host disease (GVHD), in which donor cells can attack the recipient’s tissues, appears to occur less frequently with cord blood than with bone marrow. This may be because cord blood has a muted immune system and certain cells, usually active in an immune reaction, are not yet educated to attack the recipient. However, in the production process includes a method to extract the CD34+ and CD133+ stem cells using magnetic beads. Consequently matching is no longer required and the treatment in this format carries no associated risks.
Umbilical cord cells can be stored and transplanted back into the donor, to a family member or to an unrelated recipient. More technically, stem cells from umbilical cord blood have the advantages of naive immune status and relatively unshortened telomere length. In other words, these cells have the ability to transform into most of the other cells in the body. UCB is separated by sequential immunomagnetic removal of nucleate granulocytes, erythrocytes and haemopoietic myeloid/lymphoid progenitors.
Procedure and Schedule
Upon arrival at the hospital, you will be given standard tests to check your health and the details of your condition. The usually include blood, urine, stool, blood pressure, mobility, an ultrasound, an EMG and a breath test. You also will have an MRI or CT scan if appropriate and you do not have recent one. You will then be given enough time to recover after your trip and will then receive your first injection of stem cells. Some patients prefer to wait a day or two to get settled in before taking all the tests as they are quite thorough and can be strenuous after a long trip.
The procedure can be done in two ways. For those who are not comfortable having an injection in their spinal cord fluid, they can have an IV in their hand of a mix of stem cells and nerve growth factors. This will be repeated at every 5 to 7 days until the treatment course is finished. The treatment is usually done around 3:30 p.m. and is painless except for the pinprick.
For those who are open to having an injection in their spinal cord fluid, the procedure is done under local anesthesia – an injection into the skin at the site of the following injection into the spinal cord fluid – followed by an intrathecal injection (into the fluid around the spinal cord – see diagram). Immediately after the needle enters your spinal cord fluid space, some spinal fluid is drained out and then is replaced with three injections of stem cells. In general, the process takes about 30 minutes in total and there will be pain for between 15 to 30 seconds from the anesthetic injection.
This procedure is followed by an IV of nerve growth factors to stimulate the growth of the stem cells.
Depending on the disease after the first injection you may or may not feel some changes. Five to seven days after your first injection, you will receive the second injection. Then every five to seven days after you will receive the next series of injections until your treatment cycle is over. At the end of your stay, you will receive a final series of tests. You will be interviewed at the end of your stay to gauge the improvement.
Rehabilitation
It
is recommended that patients do rehabilitation on as many of the days they feel
up to it – except for Sunday or the injection day when most therapists have
their day off. After the initial check-up, the doctor will prescribe a daily
rehabilitation schedule which will consist of one to three hours in the morning
and one to three hours in the afternoon.
The Department of Rehabilitation at Nan Shan Hospital is one of the leading rehabilitation departments in the Guangdong Province. was established in March 2004, and is an independent department located on the fourth floor of the hospital. It is comprised of 300 square meters of treatment area, including six therapy rooms and a large open gym. The Department offers a variety of programs in the areas of Physical Therapy, Occupational Therapy, Speech Therapy, Acupuncture, Manipulation and ADL (Activities of Daily Life) education, in order to meet the needs of patients during their stay here. The equipment available to patients ranges from a CPM shoulder/leg rehabilitation machine to several prone and supine standers, leg and arm exercising machines, stationary bicycles, a suspension harness attached to a treadmill for gait training, and all the standard weight and gait training accessories. The staff in the Department of Rehabilitation is strongly committed to teaching and contributing to shaping the future of rehabilitation practices. At present, there is one attending physician for treatment, one assistant attending for treatment, one assistant attending for nursing, two resident supervising doctors, and six rehabilitation therapists, including one with a Ph.D. degree, and two with Master’s degrees. The mission of Nan Shan’s Rehabilitation Department is "to empower individuals with disabilities to achieve a greater quality of life through effective treatment.”
3. B E I K E B A C K G R O U N D
Beike is a bio-technology company that was founded with capital from Beijing University, Hong Kong University of Science and Technology and Shenzhen City Hall. It is also supported with funds from the China State National Fund. The research and clinical work comes as a collaboration of Beijing University, Hong Kong University of Science and Technology, No. 3 Army Medical University, Zhongshan Medical University, Guiyang Medical College and Zhengzhou University. Throughout all of our collaborating laboratories, we have over 60 Ph.D. researchers focusing on stem cell research. The company was formed in January of 2005 after the collaborating scientists felt comfortable enough with their years of research and clinical experience to begin treating patients with stem cells on a commercial scale.
The management, researchers and doctors have been
focused on stem cell and other biomedical research since 1999. We have been
treating patients with stem cell injections since 2001. As of January 1st,
2005, we have treated over 600 patients with stem cell injections with the most
being for ALS (120+), Brain Trauma (40+), Cerebral Infarction (40+), Cerebral Hemorrhage (25+), Cerebral Palsy (20) and diabetic
foot/arteriosclerosis (200+). We
have treated patients for other diseases including Alzheimers,
Autism, Encephalatropy,
Guillain-Barre,
Multiple Sclerosis, and Spinal Cord Injury. We are currently
treating patients at hospitals in Chongqing, Shenyang, Qingdao, Shenzhen and Zhengzhou
and, concentrating on using chord blood stem cells for treatment. Our treatment
involves injections into the spinal chord fluid or intravenously and is usually
an outpatient treatment involving no surgery.
Our main research lab is located in Shenzhen Hi-tech Industrial Zone with support from scientists from all of the collaborative universities. The Shenzhen Hi-tech Industrial Zone is one of the five large industrial zones with key focus from the Chinese central Government. With the support of the Shenzhen City Hall and the Shenzhen Hi-tech industrial zone, Beike has been able to develop extremely rapidly. We are one of the leading expert groups in China for separating purifying, nurturing, and multiplying embryonic, fetal, adult and most importantly – blood chord stem cells. We have been able to grow human organ cells as well which will pave the way for future cures.
Beike’s greatest strength and the key factor which differentiates us from other research initiatives is that we specialize in clinical applications. We know there are a lot of patients in countries around the world who could have a better quality of life and even extend their lives with the technology available but don’t have the chance because of politics, religion and bureaucracy. Our goal is to help those people. We take the most advanced biotechnological research in the world, specifically stem cell therapy, and apply it clinically at a rapid pace. This allows us to achieve our mission of:
“Tomorrow’s Treatments, Today.”
4. D R . Y A N G ‘ S B A C K G R O U N D
Curriculum Vitae
Name: Yang Bo
Sex: Male
Birthday: January 19, 1963
Address:
P. R. China Department of Neurosurgery
The First Affiliated Hospital
Zhengzhou University
Zhengzhou City, 450052
P.R.China
EDUCATION
1988 - 1991 M.S, Department of Neurosurgery, Henan Medical University
1980 - 1985 M.D, Henan Medical University
FACULTY APPOINTMENTS
1985 – 1990 Resident, Department of Neurosurgery, First Affiliated Hospital of
Henan Medical University
1990 - 1995 Attending Surgeon, Department of Neurosurgery, First Affiliated Hospital of
Henan Medical University
1995 - 2001 Associate professor, Department of Neurosurgery, First Affiliated Hospital of
Henan Medical University
2001 - present Professor of Neurosurgery, Department of Neurosurgery, First Affiliated Hospital of
Henan Medical University
RESEARCH EXPERIENCE
1989 - 1992 Henan Medical University
The studies of Transcranial Doppler (TCD) ultrasonography in Neurosurgery and Neurology, including acute brain injury, increased intracranial pressure, brain death, arteriovenous malformation of brain, cerebral embolism, cerebral haemorrhage, cerebral hyperperfusion, cerebral hypoperfusion, cerebral infarction, cerebral ischemia, cerebral vasospasm, etc.
1993 - 1997 Henan Medical University
The study of Stereotactic and Functional Neurosurgery, including study of treatment of Parkinson’s disease; Stereotactic biopsy and treatment of deep intracranial lesions; Stereotactic intracranial tumor irradiation with nuclide for craniopharyngiomas; Radiofreguency treat the trigeminal neuralgia; Application of radiofreguency capacitive hyperthermia for deep-seated brain tumor; CT-guided stereotactic craniotomy; Evaluation of the factors affecting the therapeutic results of interstitial brachytherapy on brain tumors.
1998 Beijing Hospital, Beijing Tumor Hospital and Henan Medical University
Studies on the treatment of intracranial tumour by linac stereotatic radiosurgery (X knife). Including radiobiology of radiosurgery; Linac stereotatic radiosurgery for brain metastasis; Methodology and efficacy evaluation of Linac-based radiosurgery for pituitary adenomas; The effect of radiosurgery on the proliferation of meningioma cell.
1999 - present Henan Medical University
Neural stem cell culture and transplantation including isolation of human embryonic neural stem cells, adult neural stem cell from the cerebral tissue of patients while neurosurgical operation and performing clinical self-transplantation, Neural stem cells transplantation in Parkinson’s disease, brain injury, spinal cord injury and stroke. In early stage, the studies including isolation, culture, and preservation of neural stem cells from embryonic rat; transplantation of neural stem cell in animal models of brain injury and spinal cord injury.
2004 -04 --- 2004 -09 Albert Einstein College of Medicine and Moffitt Cancer Center
Neural stem cells transplantation in Parkinson’s disease, brain injury, spinal cord injury and stroke.
TECHNICAL SKILLS
Transcranial Doppler (TCD) ultrasound; stereotactic and functional neurosurgery; linac stereotatic radiosurgery (X knife), cell culture and neural stem cells transplantation in humans and animals.
PUBLICATIONS
1 Yang Bo, Feng Zuyin. Evaluation of brain death by using transcranial Doppler. Chinese Journal
of Traumatology, 1991,7:83-84
2 Yang Bo, Feng Zuyin. Transcranial Doppler monitoring on the patients with head trauma. Chinese Journal of Traumatology, 1992,8:68-71
3 Yang Bo, Feng Zuyin. Prognostic value of middle cerebral artery blood flow velocity in acute severe brain injury. Chinese Journal of Neurosurgery. 1992,8:209-211
4 Yang Bo, Feng Guohui, Ren Guoxing, et al. The effect on blood flow velocity of middle cerebral artery after acute increased intrancranial pressure in rabbits. Chinese Journal of Traumatology, 1992,8:68-71
5 Yang Bo, Feng Zuyin, et al. Effect on free radical reaction and pathomophism of brain due the
changes of the flow velocity of middle cerebral artery after acute increased intracranial pressure in rabbits. Chinese Journal of Nervous and Mental Diseases, 1992,18(6):321-323.
6 Yang Bo, Feng Zuyin. Transcranial Doppler in the evaluation of brain death. Stroke,
1994,25(3):755
7 Yang Bo, Feng Guohui, Ren Guoxing, et al. Effect on blood flow velocity due to acute increased intracranial pressure in rabbits. Chinese Journal of Traumatology, 1995;11(1):41
8 Yang Bo, Feng Zuyin, Song Laijun, Wei Li, Wang Jiang, Zhang Ali. The Pathological anatomy
changes after interruption of diastolic blood flow in Middle Cerebral Artery due to increased intracranial pressure in rabbits. Journal of Henan Medical University, 1995, 30(3),Sep:193-194
9 Yang Bo, Feng Zuyin, Song Laijun, Fu Lei. The Effect on brain free radical of the blood flow velocity in Middle Cerebral Artery after increased intracranial pressure in rabbits. Journal of Henan Medical University, 1995, 30(3),Sep:194-195
10 Yang Bo, Chen Yanbin, Yang Shuqin, Feng Zuyin, Zhang Zhiqiang, Song Laijun, Yang Chenghong. Transcranial Doppler used in rabbits and patients with head injury after administration of venoruton——animal experiment and clinical case report. Journal of Henan Medical University, 1995, 30(3),Sep:201-204
11 Yang Bo, Feng Zuyin, Song Laijun, Wang Shukai, Bao Jianji. The Observation of acute brain injury with transcranial Doppler ultrasound. Journal of Henan Medical University, 1995, 30(3),Sep:206-207
12 Yang Bo, Feng Zuyin, Zhang Zhiqiang, Song Laijun, Sun Hongwei. The Observation of Mannitol role on head and brain injury by transcranial Doppler sonography. Journal of Henan Medical University, 1995, 30(3),Sep:207-208
13 Yang Bo, Feng Zuyin, Zhang Zhiqiang, et al. A transcranial Doppler study of drainage of cerebrospinal fluid and intracranial hematomas. Journal of Henan Medical University,
1995,30(1):210-214.
14 Yang Bo, Zhang Qiang, Liu Shujun, et al. Study of Hemodynamics Monitoring and
Signifcance in the Embolization of Arteriovenous Malformation. Chinese Journal of Medical Imaging Technology, 1999,15(12):921-923
15 Yang Bo, Zhao Jianying, Lu Guojun, Song Laijun, Li Li, Zhang Zhengyong, Liu Shujun, Chen Xizhong. Fabrication and application of multi-directions hitting machine for making brain injury. Journal of Henan Medical University, 1999,34(3)Sep:1-2
16 Yang Bo, Zhang Zhengyong, Chen Xizhong, Son Laijun, Zhao Jianying, Lu Guojun,. Effects of dexamethasone by local treatment on brain pathology after brain injury in rabbits. Journal of Henan Medical University, 1999,34(3):3-5
17 Yang Bo, Miao Peiqian, Li Li, Zhang zhengyong, Lu Guojun, Zhao Jianying, Liu Shujun, Chen Xizhong. Effects of local anisodamine treatment on rabbit cerebral blood velocity after brain injury. Journal of Henan Medical University, 1999,34(3):6-8
18 Yang Bo, Li Jinghong, Zhang Qiang, Song Laijun, Zhang Zhengyong, Lu Guojun, Zhao Jianying, Li Li. Effects of dexamethasone by carotid injection on serum myelin basic protein after brain trauma of rabbits. Journal of Henan Medical University, 1999,34(3)Sep:9-11
19 Yang Bo, Zhang Qiang, Ren Guoxing, et al A Transcranial Doppler Study on the Application of Mannitol by Carotid Artery After Brain Injury in Rabbits. Chinese Journal of Medical Imaging Technology, 2000,16(8): (to be determined)
20 Yang Bo, Zhang Qiang, Song Laijun, Zhao Jianying, Lu Guojun, Zhang Zhengyong, Li Li, Liu Shujun. The treatment of brain injury with injection of Monosialoganglioside by internal carotid artery in rabbits. Journal of Henan Medical University, 1999,34(3)Sep:12-13
21 Yang Bo, Lu Guojun, Zhao Jianying, Song Laijun, Zhang Qiang, Zhang Zhengyong, Li Li,Chen Xizhong. Effects of brain blood flow velocity and edema by puncture administration of Anisodamine to External Carotid Artery of rabbits. Journal of Henan Medical University, 1999,34(3)Sep:13-14
22 Yang Bo, Du Ying, Li Li, Zhang Zhengyong, Zhao Jianying, Lu Guojun, Liu Shujun, Chen Xizhong. Effects of experimental rabbit brain injury on proliferation of splenocytes. Journal of Henan Medical University, 1999,34(3):15-17
23 Yang Bo, Guan Fangxia, Zhang Qiang, Song Laijun, Liu Shujun, Chen Xizhong, Zhao Jianying, Lu Guojun. The Effects of fastigial nucleus stimulation on cerebral blood flow velocity and intracranial pressure of patients with brain injury. Journal of Apoplexy and nervous diseases, 2000,17(3):147-148
24 Yang Bo, Guan Fangxia, Cheng Jingliang, Song Laijun, Liu Shujun, Chen Xizhong, Zhao Jianying, Lu Guojun. Study of local treatment of dexamethasone on rabbit brain magnetic resonance imaging, electroencephalogram and ultrastructure. Chinese Journal Of Medical Imaging Technology, 2000,16(8):697-698
25 Yang Bo, Guan Fangxia, Song Laijun, Liu Wanhua, Liu Shujun, Chen Xizhong, Tang Yanhua, Li Fang. Study of Telomerase expression on intracranial neuroepithelial tumors. Chinese Journal Of Medical Imaging Technology, 2000,16(12):1032-1033
26 Yang Bo, Guan Fangxia, Liu Wanhua, Song Laijun. Effect of dexamethasone by local treatment on cerebral edema and serum myelin basic protein after brain injury in rabbits. Chinese Journal of Traumatology(English Edition), 2000,3(4):231-233
27 Yang Bo, Guan Fangxia, Liu Shujun, et al. Experimental Study of Effects of Topical Application of Dexamethasone on Cerebral Edema and Brain Injury.13th Meeting of International Neuro-Opthalmology Society, INOS-2000 September10-13, 2000, Toronto, Ontario, Canada.Neuro-Opthalmology, 2000, 23(3-4):241.
28 Yang Bo, Guan Fangxia, Liu Shujun, et al. A Transcranial Doppler Study of Topical Application of Dexamethasone after Brain Injury in Rabbits. 13th Meeting of International Neuro-Opthalmology Society, INOS-2000 September10-13, 2000, Toronto, Ontario, Canada. Neuro-Opthalmology, 2000, 23(3-4):241
29 Yang Bo, Du Ying, Zhang Qingyong, Song Laijun, Wang Shukai, Zhang Zhiqiang. Isolation and culture of neural stem cells from embryonic human. Journal of Henan Medical University, 2000,35(6):504-505
30 Yang Bo, Liu Shuxiang, Miao Peiqian, Guan Fangxia, Song Laijun, Liu Wanhua, Liu Huifan, Ren Xinmin. Telomerase expression of cerebral fluid specimens in intracranial tumors and significance. Chinese Journal Of Medical Imaging Technology, 2001,17(8):719-720
31 Yang Bo, Xu Yuming, Zhang Shifeng, Song Laijun. A transcranial Doppler study of locally using dexamethasone after brain in rabbits. Modern Rehabilitation, 2001,5(2):154-155
32 Yang Bo, Tan Zhanguo, Zhao Xinli, Song Laijun. Noninvasive evaluation about craniocerebral injury. Modern Rehabilitation, 2001,5(10):21-25
33
Yin Weidong, Hao Guanyi, Song Laijun, Yang Bo.
Temperature measurement technique after mild hypothermia
treatment in brain injury rats. Journal of
34
Tan
Zhanguo, Feng Zuyin, Zhang Zhiqiang, Yang
Bo, Chai Zongju.
Effects of indomethacin on acute brain injury
observed with transcranial Doppler monitoring.
Journal of
35 Yan Dongming,
Zhang Zhiqiang, Zhang Junjie,
Bao Jianji, Yang Bo.
Effects of mild hypothermia on expression of c-fos after experimental brain injury in rabbits.
Journal of
36 Yang Bo, Song Laijun,
Liu Shujun, Zhao Jianying,
Lu Guojun, Li Li, Cheng Xizhong, Zhang zhengyong. TRANSCRANIAL DOPPLER STUDY OF LOCAL APPLICATION IN BRAIN OF
ANISODAMINE AND DEXAMETHASONE IN RABBITS. Asian Symposium on Neurosonology and Cerebral Hemodynamics,
P80,
37 Zhao Xinli, Yang Bo, Du Ying, Neuroepithelial Stem Cell Protein (Nestin),
Journal of
38 Zhang Qingyong,
Yang Bo, Zhao Xinli, He Wei,
Song Laijun, Li Hongwei.Culture
and identification of embryonic rat neural stem cells. Journal of
39 Du Ying，Zhao
Xinli，Yang Bo，RUAN
Lirong， SONG Laijun，LI Hongwei
Proliferative properties in vitro of adult rat neural
stem cells from different brain regions. Journal of
40 Zhao Xinli，Yang
Bo，Song Laijun，DU
Ying ,RUAN Lirong，LI Hongwei
，ZHANG
Zhiqiang. Cryopreservation and thawing of human embryonic neural stem cells. Journal
of
41 Du Ying，Ruan Lirong，Yang Bo， LI Qianru，ZHAO Xinli，LI Hongwei，ZHANG Qingyong，SONG Laijun. Isolation and purification of the human embryonic neural stem cells with immunomagenetic method. Journal of Zhengzhou University(Medical Sciences), 2003,38(1):13-15
42 Du Ying，Yang Bo，Ruan Lirong， Zhao Xinli, Li Hongwei，Song Laijun .Influences of leukemia inhibitory factor on the proliferation and differentiation of human embryonic neural stem cells. Journal of Zhengzhou University(Medical Sciences), 2003,38(1):16-18
43 Zhao Xinli，Yang Bo， Li Hongwei，XU Yuming，Du Ying，Ruan Lirong， Zhang Qingyong，SONG Laijun. Influences of GM-1 on the proliferation and differentiation of neural stem cells. Journal of Zhengzhou University(Medical Sciences), 2003,38(1):18-20
44 Ma Xifeng ，Yang Bo，Ren Xinmin，Tang Yanhua，Zhao Jianying，Zhang Zhengyong，Song Laijun，LI Huixiang. Study on transplantation of cultured embryonic neural stem cells for rat spinal cord complete transection models. Journal of Zhengzhou University(Medical Sciences), 2003,38(1):21-23
45 Yang Bo，Fu Zhenfeng, Wang Wu, Zhang Meiling, Song Laijun，Zhang Qingyong. Transplantation of cultured embryonic neural stem cells for rat brain injury models. Journal of Zhengzhou University(Medical Sciences), 2003,38(1):23-24
46 Yang Bo, Tang Yanhua, Zhao Jianying, Song Laijun, Guan Fangxia,Liu Wanhua, Liu Huifan, Ren Xinmin, Zhang Zhengyong. The changes of cerebral blood flow velocity and brain lesion in patients with brain injury after fastigial nucleus stimulation. Chinese Journal Of Medical Imaging Technology, 2002,18(2):118-120
47 Yang Bo, Zhang Jing, Xu Yuming, Song Laijun, Zhao Jianying, Ren Xinmin, Zhang Zhengyong, Tang Yanhua. Experimental study on effects of dexamethasone on cerebral edema and serum myelin basic protein after brain injury in rabbits by local treatment. Chinese Critical Care Medicine, 2002,14(1):38-40
48 Yong Man, Hong-Wei Li, Bo Yang,Jian Rui-Sun,Qing-Yong Zhang, Lai-Jun Song, Effects of different dose of ganglioside on proliferation and differentiation of neural stem cells. Chinese Journal of Clinical Rehabilitation,2004,8(22):4634-4635
49 Yong Man, Hong-Wei Li, Bo Yang, Jian Rui-Sun, Lai-Jun Song, Qing-Yong Zhang.
Transplantation of neural stem cells for repair and regeneration of Neurons and neural cycle in experimental rats with cerebral contusion and laceration. Chinese Journal of Clinical Rehabilitation,2004,8(25):5418-5419
50 Yang Bo.Treatment on amyotrophic lateral sclerosis(ALS)by transplantation of bone marrow mesenchymal stem Cells(BM-MSC).The Third International Symposium of Stem Cell.Sep.15-17,2004,Shenyang, China. P22
51 SUN Jianrui, YANG Bo, DU Ying, SONG laijun, LI Guoxi, ZHANG Qingyong, HU Xiang, HU Pingsheng, XU Hong, WANG Yunlong. Effects of dispaseⅡ on isolating neurospheres. Journal of Zhengzhou University(Medical Sciences), 2005,40(3):450-453
BOOKS
1 Yang Bo, Ren Guoxing, Feng Guohui
《Application and Practice of Transcranial Doppler Ultrasound》
Date of Published: December, 1995. ISBN 7-5369-2405-4/R.57
Shan Xi Science and Technology Press, Xi An City
2 Yang Bo, Song Laijun, Wu Baoping, Zhang Jinyao
《Concise Transcranial Doppler Ultrasonography》
Date of Published: April, 1997. ISBN 7-81048-140-1/R.138
Henan Medical University Press, Zhengzhou City
3 Zhang Zhiqiang, Feng Zuyin